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CBD BLOG

Learn More About CBD & Healthy Living!

  • Tanya Milin

CBDA stands for cannabidiol acid. It has not made much of its rounds in the market but it is beginning to create quite a stir. It is expected to change the outlook of managing long-standing pain by its revolutionary mechanism of action.


This compound has not only shown improvements for the bedridden but also for the apparently normal healthy individuals as well. It not only boosts the immune system but has also been shown to inhibit the growth of certain cancers. With much more to be known about this miraculous compound, ongoing research and studies are being carried out to determine its full potential.


What is CBDA and where does it come from?

CBDA is an active component found in the plant of cannabis. However, it has nothing to do with the state of ‘intoxication’, as most would suspect. The reason for that is pretty simple and basic; the main psychoactive compound that registers the body to get ‘high’ is THC (tetrahydrocannabinol) in the cannabis plant and not CBDA.


CBDA is actually the acidic form of CBD (cannabinoid) that is found in fresh or raw cannabis. Both of them are far away from producing any grade of intoxication.


The science behind CBDA and chronic pain




Contrary to popular belief, pain is not generally a bad entity; it helps to localize the damage and becomes an indicator of what might be going wrong in the body. However, pain that persists for a long duration and stays there for life cannot be considered a blessing.


Pain that stays for more than three months is considered ‘chronic' and deeply affects the quality of life of a person experiencing it. Its sufferers are seen to have a sedentary life with almost nothing to look forward to, in the long run.


There are a lot of diseases to date, that causes chronic pain; such as arthritis, fibromyalgia, multiple sclerosis, etc. Hence over the centuries, many new drugs have been introduced in the market to help alleviate it, but everything has come up with a cost of side-effects, with nothing too outstanding to say the least.


The main pathway of pain includes the enzyme; cyclo-oxygenase 2 (COX-2) that releases prostaglandins. Prostaglandins are the main initiators of activating the pain pathway. However, there is another pathway that is regulated by COX1, which produces prostacyclins, this compound is a powerful vasodilator and helps prevent clots in the blood vessels. This ultimately saves a person from having strokes.


Since these two products get formed side by side, a lot of medications that have been introduced to block or inhibit the COX-2 pathway, have most often disturbed the COX-1 pathway as well. This has turned fatal for the patients as they have endured a serious risk of getting strokes.


This is where CBDA came into play. According to excessive researches and studies being carried out, CBDA has proved to be a selective COX-2 inhibitor, which means that it only inhibits the pain pathway and stops the inflammatory prostaglandins, without inhibiting or causing any changes in the COX-1 pathway.


Other alternatives for the management of pain are our extremely overused drugs in the market; nothing other than the NSAIDs. These medicines are not just responsible for causing kidney problems but also become a serious threat to patients of old age, as it increases the risk of gastrointestinal bleeds to a remarkable extent. This is one of the biggest complications of NSAIDs and its excessive use for chronic pain. Hence, scientists and doctors had been on the lookout for something with lesser side-effects, little did they know that nature had its very own plant containing this element.


How is CBDA different from CBD and why is it preferred for treating long-term pain?




CBDA after going through the process of decarboxylation gets converted to CBD. CBD has been in the market for quite some time now and it has also shown promising results in the treatment of anxiety, epilepsy, reducing weight and whatnot. It has also been shown to have anti-inflammatory precursors and hence can be used for the management of pain. However, when it comes to comparing CBD with CBDA, the choice becomes pretty simple and transparent.


CBDA is a much more potent anti-hyperalgesic than CBD. The answer lies in the core structure of the compound itself. It has a carboxylic moiety that becomes the key element in inhibiting the COX-2 pathway, whereas, CBD just mimics the activity of the endogenously produced endocannabinoids and ultimately affects the endocannabinoid system inside the body.


CBDA however, has the same structure as the endogenous compound that inhibits the pain pathway and gives an almost equal effect as the opioids themselves. To manage pain, CBDA works twice more effectively than CBD. A study that was conducted in Canada showed that CBDA was at least a thousand times more potent than CBD. Also, it could easily bind to specific serotonin receptors that also acted as a great mood stabilizer.


CBD, however, is a much more stable compound and has its own set of benefits. It has not only shown marked progress in the field of neurology but has also shown to be helpful for diabetics. Moreover, it is also thought to be therapeutic for patients of epilepsy. It has also seen to alleviate inflammation. The way CBD works is because of its amazing anticholinergic properties, which makes it clear as to how it helps counter anxiety and also decreases the occurrence of epileptic seizures.


CBDA Can Be Helpful For The Young And The Old


The great company CTFO, has managed to make patented products that include not just CBDA and CBD as part of their ingredients. These not just offer pain relief, but some of their products offer anti-aging as well as health-protective benefits.


Two of its very promising products have been briefly discussed. However, it is advised not to start on any of them without your doctor/physician’s approval.


10X PURE GOLD / SUPER 1000 CBD OIL DROPS


CTFO (Changing the future outcome) stands true to its name as it has formulated a variety of products that contain CBDA, 10x Super Gold 1000 is one of them. This product contains CBDA in an oil emulsion; it is super absorbent as it is hydrophilic. It can be applied very easily at the site of pain. Since it is a product that can be applied topically, anyone using it has nothing to worry about having long term side effects.


The biggest hallmark that CTFO has made is by making CBDA ‘stable.’ The reason why CBDA wasn’t as popular in the medical world as it is becoming now is that CBDA was highly unstable. It almost automatically got converted to CBD. A little amount of heat, air or pressure was enough to cause its transformation and hence decreased its medicinal value. CTFO however, packaged it in capsules, tinctures, creams and oil emulsions making sure that it does not change its form.


The 10x Super Gold 1000 is not just for the sick and patients suffering from debilitating illnesses but can be used by anyone who wishes to stay healthy. It has shown to boost energy levels and act as a prebiotic. This does not only ensure a healthy body but also prevents any possible illness catching up by boosting up the immune system up a notch.


10x PURE Gold Roll-On


Another amazing product that CTFO has introduced is the 10x Pure Gold Roll-On. It contains a mixture of ingredients that only makes it one of the best pain relief roll-ons to exist. It not only contains CBDA but also contains 500mgs of CBD. With their synergistic effect, relief from chronic pain can be achieved in a much shorter duration.


All the ingredients that are packaged in the 10x Pure Gold Roll-On, not just have their own benefits but together they work in miraculous ways as it contains emu oil, warming camphor as well as menthol.

Emu oil is a well known anti-inflammatory agent that not only moisturizes the skin but also leaves an anti-aging effect on it. Camphor is one of its active ingredients that help tone down swelling at much faster rates. Menthol present in this aids not just by providing a cooling effect to the part of the area inflamed, but it also helps increase the blood flow towards the area, so that healing can take place more efficiently.

The 10x Pure Gold Roll-On is packaged in a way that it does not get destroyed by heat, sunlight, air or by any other environmental factor so that all the elements that reside inside of it remain safe from destruction.


The fact that this can be applied at the site of pain makes it all the more convenient. Since, its topically applied, anyone using it has nothing to worry about any kind of idiopathic reactions that may take place, making it one of the best products to make the never-ending pain, if not disappear, then decrease to a considerable amount.


Conclusion


CBDA and CBD are not very different from each other. Both these products have changed the outlook of managing many chronic diseases that previously didn’t have any promising treatments. The discovery of these compounds shows great potential in treating the ones suffering alone.


A trial conducted in Canada by the Department of Psychology and Collaborative Neuroscience Program, tested on rodents and results of it proved that CBDA worked for not just chronic but also in acute pain conditions as well. A study has also put forth that CBDA has shown to halt the process of breast cancer spread. A lot more trials and studies are underway to completely confirm the theory but it does shed a lot of light on the ones who have lost all hope.


This magical drug has yet to get its approval by the FDA, but as soon as that happens it will be one of the biggest hallmarks in the history of science, for extracting something so beneficial from the plant of cannabis.


As many more studies will see the light of the day, it's only then we can tell how safe the use of CBDA and CBD will be. It hasn't been shown to present with any extreme side-effects as of yet. It is, however, not advised to start using products containing either CBD or CBDA without a doctor’s approval.


References


Takeda S, Misawa K, Yamamoto I, Watanabe K, (2008), ‘Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis.’ Drug Metab Disposposition: the biological fate of chemicals. 2008 Sep;36(9):1917-21. doi: 10.1124/dmd.108.020909.


Rock EM, Limebeer CL, Parker LA. (2018), ‘Effect of cannabidiolic acid and ∆9-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain’, Psychopharmacology (Berl). 2018 Nov;235(11):3259-3271. doi: 10.1007/s00213-018-5034-1..


Citti C, Pacchetti B, Vandelli MA, Forni F, Cannazza G., (2017) ‘Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA).’ J Pharm Biomed Anal. 2018 Feb 5;149:532-540. doi: 10.1016/j.jpba.2017.11.044


Baron EP, Lucas P, Eades J, Hogue O. (2018) ‘Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort’. J Headache Pain. 2018 May 24;19(1):37. doi: 10.1186/s10194-018-0862-2.


Russo EB. (2018), ‘Cannabis Therapeutics and the Future of Neurology’. Front Integr Neurosci. 2018 Oct 18;12:51. doi: 10.3389/fnint.2018.00051.


Sumariwalla, P. F., Gallily, R., Tchilibon, S., Fride, E., Mechoulam, R., & Feldmann, M. (2004). A novel synthetic, non-psychoactive cannabinoid acid (HU‐320) with antiinflammatory properties in murine collagen‐induced arthritis. Arthritis & Rheumatism, 50(3), 985-998.


Takeda, S., Misawa, K., Yamamoto, I., & Watanabe, K. (2008). Cannabidiolic acid as a selective cyclooxygenase-2 inhibitory component in cannabis. Drug Metabolism and Disposition, 36(9), 1917-1921.

  • Tanya Milin


It’s not always easy to work out which CBD product is best for you, so we’ve compared four great CBD products and what they’re best suited too!


When it comes to CBD products, there is a lot of choices. For anyone new to CBD, it’s not always easy to determine which CBD product is best suited to you and what separates it from other CBD products. To make things a little easier, we are going to compare four different types of CBD products and help you identify what separates them from other CBD products.


CBD products have the potential to support healthy blood sugar levels, relieve anxiety, boost energy levels, assist digestion, support healthy immune systems, and promote an overall sense of well-being and health.


10xPure vs. 10xPure Gold vs. Full Spectrum vs. Isolate CBD Oils

Each of the CBD oral drops can also be used topically. They all have their own benefits, so it’s important that you choose the best product for you. What works for one person may not always work for someone else.


One of the biggest differences between the different CBD products is their THC content. 10xPure and 10xPure Gold have less than 0.03% THC, Full Spectrum has less than 0.03% THC, and the Isolate CBD Oil has 0% THC.


Each of the CTFO CBD products is produced from non-GMO, organic hemp plants. CTFO CBD products are GMP Certified, and you can order with peace of mind knowing that you’re getting a premium CBD product.


10xPure CBD Oil

The 10xPure range of supercharged CBD Oil was shown in testing to help maintain and also protect the integrity of CBDA. CBDA has been shown in some studies to be even more beneficial than CBD.

Bioavailability is very important when it comes to choosing a CBD Oil that’s best suited to you. 10xPure CBD Oil is Hydrophilic. This means that it can be mixed with water or other water-based drinks. It will give you faster and better absorption and potency. 10xPure CBD Oil supports better overall health and wellness.


10xPure Gold Super 1000 CBD Oil

If you want to supercharge your CBD Oil, then the 10xPure Gold CBD Oil is the product for you. 10xPure Gold CBD Oil is Hydrophilic, which means that it mixes with water. Why is this important? Because 10xPure Gold CBD Oil will give you better bioavailability. This means that more of the important CBD is making its way into your bloodstream.


The 10xPure Gold Supercharged is specially formulated for pain relief and inflammation. It has been enriched with a blend of CBDA and also all the benefits of a full spectrum CBD Oil.


Full Spectrum CBD Oil

Did you know that there are over 85 different cannabinoids and phytonutrients in each Full Spectrum CBD Oil? On average, each Full Spectrum CBD Oil contains almost 16-23% CBD, one of the most beneficial cannabinoids for boosting overall health and wellness. They also contain less than 0.03% THC. Which means that they’re completely legal!


When you choose a full spectrum CBD oil product, you get to enjoy the full benefits of the entourage effect. This is when all the cannabinoids, flavonoids, terpenes, and other plant nutrients work together in synergy. When all these elements work together, you get much more of an all-round effect from CBD Oil.


Isolate CBD Oil

When you purchase an Isolate CBD Oil, you’re getting a CBD Oil that has had all other cannabinoids and terpenes removed from it. CBD Isolate Oils are 95-99% pure CBD. The only downside to CBD Isolate is that you don’t get the full entourage effect you would experience with a full spectrum CBD Oil.


The upside to this is that you’re getting a CBD Oil which is 100% THC free. This is particularly useful if you have to take drug tests as part of your employment. All CTFO CBD Topicals are manufactured using CBD Isolate. This is an ideal way to experience the full benefits of CBD.


It’s important that you speak with your doctor or healthcare professional before ceasing or switching your current medication. Dosages of CBD oil products will vary from person to person. It’s recommended that you start off with small dosages and then increase your dosage until you find a comfortable level that suits you.

  • Tanya Milin

CBD is the short abbreviation for cannabidiol; it is among the many chemical compounds, or cannabinoids, found in hemp and marijuana. There are a lot of benefits in CBD, the major being that CBD is not psychoactive, so as to say it's not what gets you stoned. Research has proven that it's also different from marijuana, which has proven to reduce human pain. Cannabidiol is a much known natural remedy used for many common sicknesses. It‘s one of the over numerous chemical compounds known as cannabinoids found in the marijuana or cannabis plant (Cannabis sativa).


Tetrahydrocannabinol (THC) is the major psychoactive cannabinoid found in cannabis, and it is responsible for the sensation of getting high (disordered) that are often associated with hemp or marijuana. In other words, CBD is not psychoactive, unlike THC.


This makes CBD an attractive option for those who are looking for relief from pain as well as other symptoms without the mental-altering effects of certain pharmaceutical drugs or marijuana.

CBD oil is produced by extracting Cannabidiol from the cannabis plant and then diluting it with oil content substance like hemp seed oil or coconut.


WHAT DOES CBD IT DO?


Different research has shown that CBD is helpful by lessening anxiety for individuals who have psychosis or schizophrenia, or people who are addicted to opiates. However, because of its anti-inflammatory properties, CBD could even help treat acne according to research.

Research also has it that CBD could also be used in treating epilepsy for children, although this has not been fully authenticated.


Below are benefits of using CBD OIL and why it should be added to daily eating routine:


CBD ENCOURAGES BALANCE

CBD tends to interact with the body’s endocannabinoid system, a network which is responsible for controlling body functions like appetite, sleep, immune response and mood. The body can create its own naturally occurring cannabinoids, which then interacts with the endocannabinoid system’s which posses the cannabinoid receptors to regulate these functions.


By eking out these endocannabinoids with hemp-derived cannabinoids like CBD daily, this can help further embolden our endocannabinoid systems to achieve homeostasis within the body and when the body and its functions are in balance, you will be able to perform at your peak. 


HEMP OIL SUPPLEMENTS HEALTHY DIET

To be completely healthy, a healthy and complete diet is mandatory. A hemp oil supplement contains more than just CBD and other trace of cannabinoids. The hemp plant is a natural source of nutrients that are at-times insufficient in our daily diets; such nutrients include:


  • Vitamin E

  • B complex vitamins

  • Vitamin C

  • Omega fatty acids

  • Calcium

  • Essential amino acids

  • Magnesium


Also, hemp oil adds essential amino acids, polyunsaturated fatty acids, terpenes, chlorophyll and fiber to make sure that our body obtains the dietary requirements that are important for it to function efficiently. So adding a daily CBD supplement to your daily diets will help boost the nutritional value of that diet.


CBD OIL IS NON-INTOXICATING

CBD is not an intoxicating compound, thus making CBD hemp oil a general supplement for people of all ages. This also means that one can seamlessly add the daily nutrient and balancing benefits of hemp oil without having to think of any temporary distractions that come along with euphoric effects.


CBD products gotten from hemp contain only small traces of Tetrahydrocannabinol (THC), the compound in cannabis that is responsible for any intoxicating effects.


HOW TO ADD CBD OIL TO YOUR REGIMEN

Adding CBD to our daily regimen has been made more simple, we all know we humans have different taste and ways which we eat or incorporate things into our food, it differs so badly that Mr. A might want to add solid CBD to his tea or coffee while Mr. B detest that a lot and will rather use CBD that comes in liquid forms. This preference has made the medical companies produce different types of CBD readily available to customers in different forms and styles. Below are the ways CBD comes and selecting the one that suits one's style is a matter of choice.


CBD Oil Concentrate Oral Applicators

This comes in liquid form and it has the highest concentration of CBD, it is taken in into the body by injection method.


TOPICAL SALVES

This CBD looks like a balm; it is robbed in the body, the topical salves helps to warn and strengthen those weak muscles one contains after each workday. A topical salve is recommended to be used after a strenuous work-out.


CBD CAPSULES

This CBD comes in capsule forms; they can be taken as a supplement after food just like our usual vitamin supplements. Adding CBD capsule to your list of supplements is a good decision because it helps to maintain a healthy diet balance.


CBD TINCTURES / OILS

Because a CBD tincture is concentrated, it’s designed to be taken in small doses. This is why most tinctures come with a built-in dropper that allows users to take small, carefully measured quantities sublingually (under your tongue).


Usually, I would NOT recommend mixing CBD Oil into food and/or drink since it is not water soluble. HOWEVER, CTFO's 10xPURE line of CBDA is hydrophilic so it CAN MIX WITH WATER. It can also be added easily to drinks like coffee and tea; an evening cup of chamomile paired with CBD tincture stands to be even more relaxing than usual.


CBD VAPE PENS

This is made at high concentration and it is only recommended to those impatience ones who want to get a quick result. Right now I would NOT recommend this method as there have been some reported vape related illnesses (better safe than sorry!).


In summary, everyone takes CBD for different reasons best known to them. And while one might decide not to take CBD daily, others could be comfortable taking CBD on a consistent, daily schedule and that will surely work for his/her own needs.