• Tanya Milin

Emerging Information Regarding CBDa

Updated: Apr 27, 2019

Cannabis has become the hot topic of our era, and not only for its psychoactive cannabinoid THC. Another cannabinoid called CBDa is becoming increasingly popular for its potential health benefits, without the high. Cannabidiolic acid (CBDa) is a chemical compound found in the resin, or trichomes, of the raw cannabis plant. CBDa is what is known as the acid precursor of CBD, meaning once the cannabis plant is heated, CBDa breaks down from its acid form into CBD.

The process of converting CBDa to CBD is called decarboxylation. This is what you may find in most CBD products around. However, there is evidence to suggest that CBDa may have its own role to play in improving health.While it’s long been considered necessary to decarboxylate CBDa and transform it into CBD in order to unleash its health benefits, scientific studies are showing that CBDa may have benefits that are unique and all its own.

Like CBD, some research studies suggest that CBDa could be helpful in treating diseases such as depression and epilepsy.

Cannabidiolic acid (CBDa) was first isolated in the 50’s. Then (like most other minor cannabinoids), not a whole lot happened with it for several decades. Even as CBD research started to take off in the 90’s and 2000’s, CBDA lagged behind.

Far less research has been carried out on CBDa than on CBD. So far all studies on CBDa and what it may do, have been at the preclinical stage. No human trials have been carried out.Finally, in the last few years, research on CBDa has started to pick up. In many cases, CBDa works in the same way as CBD, but has several important advantages. Although no clinical trials on humans have started yet that I can find, I wouldn’t be surprised to see some in the future.


Studies suggest that CBDa doesn’t actually interact with the endocannabinoid system in the same way that CBD does. CBDa affects other receptors and enzymes like inflammatory mediators and TRP channels involved in pain regulation.Once again, there is a real lack on research into CBDa in human models. Much further research is needed before any firm conclusions can be drawn. As more research comes out, it has been suggested that CBD and CBDa taken together is a winning combination. Research suggests that combined, CBD + CBDa are highly effective in studies on epilepsy, nausea and anxiety treatments. The research suggests that combining CBD and CBDa will:


  1. Require smaller doses

  2. Improve the time it takes for it to be felt

  3. Increase its effectiveness


The company I represent currently offers a patented product known as 10x Pure. This product is showing in initial testing to actually protect and preserve CBDa within the body after ingestion! This exciting breakthrough is only available through CTFO. Ask me how to obtain this incredible patented product. In 2012, it was reported that CBDA enhances 5-HT1A signaling and seemed to have some potential for reduction of nausea and vomiting through this mechanism. At first glance, this wasn’t too exciting since CBD also shares this mechanism. But two things separated CBDA from CBD:


CBDA demonstrated about 100-fold greater affinity for the 5-HT1A receptor than CBD, allowing much lower doses


CBD has a bell-shaped dose-response curve for both nausea and anxiety. This means that if the dose gets too high, then it loses its effect.


Of the 100+ phytochemicals that are found in the cannabis plant, we only really have evidence on the biological and potential therapeutic effects of THCA, THCV, CBDA, CBV, CBG and CBC.


Of these, only THCV (in diabetes and metabolic disorders) and CBDV (in epilepsy and autism) have been tested as single molecules in humans.


From animal and cell line studies, we know that THCA, THCV, and CBDA may have a role in reducing nausea. CBG might also help stimulate appetite. As these compounds are not psychotropic, they may be preferential to THC, which patients often use for nausea and appetite stimulation in cancer and HIV situations.


THCA, THCV, CBG and CBC all have anti-inflammatory properties in various models, with therapeutic applications against a wide range of inflammatory disorders. CBDA, CBG and CBC have potential anti-tumoral properties. THCV and CBG might also be protective in various neurological disorders.


We can also find some additional data in various patents. For example, patents have been filed related to CBDA and:


Nausea/vomiting


Epilepsy


Autism spectrum disorders



Sources:

https://www.ncbi.nlm.nih.gov/pubmed/26381155


https://www.ncbi.nlm.nih.gov/pubmed/27438607


https://www.ncbi.nlm.nih.gov/pubmed/26439367


https://www.ncbi.nlm.nih.gov/pubmed/22963825


https://www.ncbi.nlm.nih.gov/pubmed/18556441


https://www.fundacion-canna.es/en/biological-effects-lesser-known-phytocannabinoids


https://catscientific.com/effects-thca-cbda-human-endocannabinoid-system/


https://www.medicaljane.com/cannabinoid/cbda/


http://www.extsoilcrop.colostate.edu/CropVar/documents/oilseeds/alternative_oil/potential_of_hemp_seed_oil.pdf


http://profofpot.com/cannabidiolic-acid-cbda/


https://www.cnbs.org/cannabinoids/cbda-cannabidiolic-acid/?fbclid=IwAR35LoWDQo3o7u7Zry9nXZ5Xnlud2d7nzgGePIkc9EAbtvIV8IXh5-nao4w

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